THE EFFECTS OF THE H1-RECEPTOR BLOCKERS ON ADENOSINE DEAMINASE, XHANTHINE OXIDASE AND TRACE ELEMENTS IN PATIENTS WITH CHRONIC IDIOPATHIC URTICARIA

*Velid Unsal, Ergul Belge Kurutas and Perihan Öztürk

ABSTRACT

Background: Chronic idiopathic urticaria (CIU) is widespread symptom of dermatologic diseases. But the etiology is not fully defined. ADA (Adenosine deaminase) ve XO (Xanthine oxidase) are key role in purin metabolism. Cu (Copper), Zn ( Zinc), Se (Selenium) are of vital importance for many proteins and enzymes. Our aim in this study is to investigate these parameters after treatment of CIU patients. Materials and Methods: Blood samples were obtained from 25 patiens with CIU before and after weeks of treatment with H1 –receptor blokers. Blood samples from 10 healthy volunteers were used as controls. ADA, XO, Nitric oxide (NO) and Malondialdehyde (MDA) were measured as spectrofotometric. Also, the levels of trace elements were measured with atomic absorbsion spectroscopy. Results: After treatment Zn, Se levels increased significantly(p<0,05). After treatment, Zn and Se levels approached the control group. (p>0,05) And After treatment MDA, NO, XO, ADA levels significantly decreased (p<0,05). Conclusion: After treatment,Cu, Zn, Se, MDA, NO, ADA,XO approached normal physiological levels.In CIU diesase,purine metabolism and trace element level deteriorate, lipid peroxidation increases.

Keywords: Adenosine Deaminase, Xhantine Oxidase, Trace elements, MDA.