SIGNIFICANCE OF HYPERLIPIDEMIA IN BLOOD DONATION

S. Nishat Fatima Rizvi PhD Scholar, *Dr. Tulika Chandra, Dr. Abbas Ali Mahdi and Devisha Agarwal, MBBBS Scholar

ABSTRACT

Hyperlipidemia refers to elevated cholesterol and or elevated triglyceride. Cigarette smoking is considered to be a major risk factor for ischemic heart disease (IHD), hypertension and hyperlipidemia. The aim of the present study was to assess the correlation between Hyperlipidemia with specific history of the blood donors. A total of 120 blood samples of blood donors were collected. Out of them 50 samples were found to be hyperlipidemic which were included as cases, while rest was taken as controls. Lipid Profile was assessed by fully automated analyzer (TRIGL:triglycerides),(LDL-C:LDL –Cholesterol plus 2nd generation),CHOL 2:Cholesterol Gen 2 ),HDL C 3: HDL-Cholesterol plus 3rdgeneration)-(Cobas C311-Roche Diagnostic).The smoking habit showed a significant between smoking index and hyperlipidemia. Smoking group was higher than that of control group. Results were tabulated as out of 50 hyperlipidemic, 25(50%) were heavy smokers (25.8 cigarettes per day), 15(30%) were light smokers (7.7 cigarettes per day) and 5(10%) were non-smokers. Chi square Χ2=7.00; P=0.031 Smoking is important risk factors of hyperlipidemia; there was synergistic action between smokings in the development of hyperlipidemia. Therefore, this confounding factor should be included in the donor deferral criteria which lead to further deciding the exclusion criteria for donor selection. This partly explains the pattern of smoking in progression of hyperlipidemia. It will help in making the patients safe as well as the donor deferral criteria more stringent to improve the quality of blood supply and will enable blood bankers to supply safe blood and improve the guidelines for blood safety.

Keywords: Smokers, Hyperlipidemia, Blood donors, Lipid profile.