ZINGIBER OFFICINALE EXTRACT: ANTIMICROBIAL PROPERTIES PHYTOCHEMICAL SCREENING, DRUG LIKENESS AND PHYSICOCHEMICAL STUDIES

Mohammad Arshad* and Mohd Shadab

ABSTRACT

The extract of Zingiber officinale rhizomes commonly known as ginger was obtained utilizing soxhlet extraction assembly with methanol and n-hexane as solvents. Both parts (methanol and n-hexanes) were subjected for antimicrobial screening employing disc diffusion method against S. aureus, S. epidermidis, P. mirabilis and E. Coli bacteria. Findings for antimicrobial activity portrayed that the methanol extract of ginger has more advantage over the hexane extract. The literature described that ginger extract is composed of gingerol, zingiberene, β-bisabolene, α-farnesene, shogaol, β-sesquiphellandrene and α-curcumene. The computational studies such as calculation of drug likeness and physicochemical properties were performed for all the components. The computational results showed that all the components have good bioactivity score except component-7, and out of all components, the component-2, 3, 4 and 7 were found against the Lipinski rule of five with respect to the partition coefficient. Molecular docking studies were carried out to support the experimental results which states that hydrogen bonding with the receptor is found only in case of gingerol and shogaol and both the components were found mainly in methanol extract.

Keywords: Ginger extract, antimicrobial activity, drug likeness, physicochemical and molecular docking studies.