ANTIDIABETIC AND FREE RADICAL SCAVENGING ACTIVITIES OF METHANOLIC EXTRACT OF CITRULLUS LANATUS (FRUIT RIND)
A.K.Azad*, Abdul Jalil, Debendra Nath Roy, Nazneen Ahmeda, Jeb-Un Nesa, M.Moniruzzaman, Shoumen Lasker, Irfan-Ur-Rahaman, Sharmin Akter
ABSTRACT
Free radicals are associated with Diabetes and its complications. The present study was designed to investigate DPPH scavenging in-vitro antioxidant activity and antidiabetic activity on alloxan induced diabetic mice. Mice treated with extract dose at 300mg/kg p.o, showed a remarkable decrease (***p<0.001) of blood glucose concentration at 90min and 120min compared to diabetic control group and metformin was taken as a reference standard. In this study antioxidant activity of Citrullus lanatus was IC50 was 102.51 ïÂg/ml in contrast with ascorbic acid IC50 was 36.34 ïÂg/ml.
Keywords: Antidiabetic, free radical, scavenging activity, fruit rind, Citrullus lanatus.
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