SERUM IMMUNOGLOBULIN E AND VITAMIN D3 IN BRONCHIAL ASTHMA

Dr. Muhammad Ayoob Memon*, Dr. Zaid Feroz Memon, Dr. Abeer Rafique, Dr. Muhammad Haroon Mujtaba, Dr. Ramsha Fazal and Dr. Rajesh Kumar

ABSTRACT

Objective: To determine the association of serum immunoglobulin E (IgE) and vitamin D3 in bronchial asthma. Study Design: Case control study. Place and Duration: Department of Medicine -Liaquat University of Medical and Health Sciences Hospital from January 2015- September 2016. Subjects and Methods: A sample of 100 subjects was divided into 50 cases of bronchial asthma and 50 controls. Ethical permission and consent was taken. Venous blood samples were collected. Blood complete picture, serum IgE and vitamin D3 were estimated. Performa was used for data collection. Statistix 8.1 version (USA) was used for data analysis at 95% confidence interval (P≤0.05). Results: Mean ± SD age noted in controls and cases was 52.73±7.39 and 54.42 ±5.89 years respectively. Blood Eosinophils in the in cases were noted as 5.85 ± 2.32 compared to 3.38 ± 1.72 % per μL in controls (P=0.0002). Controls showed Vitamin D3 35.24±11.74 ng/dl vs. 22.06±13.6 ng/dl in cases (P=0.0003). Serum IgE in controls and cases was noted as 80.60±15.95 and 551.5±372.31 IU/ml (P=0.0001). Serum IgE and blood eosinophils showed negative correlation with vitamin D3 (r= -0.485, P= 0.0001 and r= -0.75, P= 0.0001 respectively). Conclusion: The present study shows raised serum IgE and low vitamin D3 in bronchial asthma. Serum IgE shows negative association with vitamin D3.

Keywords: Bronchial Asthma, IgE, Vitamin D3, Eosinophils.