COMPARISON OF THE GENDER SPECIFIC HLA HAPLOTYPES DISTRIBUTION IN UZBEK PATIENTS WITH CHRONIC GLOMERULONEPHRITIS AND ESRD

M.R.Ruzibakieva*, T. U. Aripova, T. R. Hegay , A. E. Kasimov, U. K. Yuldasev

ABSTRACT

Chronic glomerulonephritis (CG), chronic renal failure (CRF) are the majority of instances to end stage renal disease (ESRD) which is the cause of renal replacement therapy. Our interest was to evaluate the possible associations of HLA class II haplotypes with ESRD according to gender specificity factors, in Uzbek population. The study was performed at the Institute of Immunology of the Academy of Sciences of Uzbekistan. We have examined 542 people of Uzbek nationality. The 225 people of these have been diagnosed with chronic glomerulonephritis, chronic renal failure complicated with end-stage, to whom the chronodialize was recommended. The control group consisted of 317 healthy individuals who are relatives of the first line of kinship. The patients were 51 female and 174 male. Among the donors were 163 male and 154 female. Positively associated haplotypes with ESRD in male patients were: DRB1*08-DQA1*01:03-DQB1*06:01, DRB1*13-DQA1*01:03-DQB1*06:02 and DRB1*14-DQA1*01:01-DQB1*05:03. The haplotypes positively associated with ESRD in female patients were: DRB1*14-DQA1* 01:01-DQB1*05:03, DRB1*15-DQA1*01:02-DQB1*06:02 and DRB1*16-DQA1*01:02-DQB1*05:02.

Keywords: HLA, chronic renal failure CRF, CKD, ESRD, glomerulonephritis.