HEPATOTOXICITY OF THE FOOD ADDITIVE POTASSIUM BROMATE ON THE FRESH WATER FISH LABEO ROHITA

Sherine Laura A., Rashmi P. T. and *Pawlin Vasanthi Joseph

ABSTRACT

Potassium bromate is a white crystalline salt of bromate ion and is soluble in water. Bromate is not an inherent component of water but traces of bromate can be found in drinking water. It is found in groundwater due to cross penetration of salt water when water source is close to sea or industrial effluent facilities. It is generated due to the conversion of bromide into bromate, containing raw waters that undergo ozonization and chlorination. The main aim of this study is to evaluate the toxic effects of Potassium bromate on the highly palatable freshwater fish Labeo rohita. LC50 for 96 hrs was determined by Probit analysis method. Sub-chronic doses of KBrO3 such as 100mg/l, 130mg/l, 160mg/l, 190mg/l was taken for study. The experimental set up was maintained for 30 days. Enzymes such as Alkaline phosphatase, Lactate dehydrogenase, Serum Glutamate Oxaloacetate Transaminase and Serum Glutamate Pyruvate Transaminase were estimated and the histopathology of the liver was studied. It is evident from the present study that fishes exposed to potassium bromate are found to have damaged liver tissues and also increased serum enzyme levels.

Keywords: Potassium bromate, Alkaline phosphotase, Lactate dehydrogenase, Serum Glutamate Oxaloacetate Transaminase, Serum Glutamate Pyruvate Transaminase, Probit analysis.