STUDY OF ACUTE TOXICITY AND ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF GREWIA FLAVESCENS JUSS WHOLE PLANT USING RATS.

G. N. Pramodini* and Dr. K. Appanna Chowdary

ABSTRACT

The study was designed to investigate the acute toxicity and anti-inflammatory effect of Grewia flavescens juss, Ethanolic extract. The effect of Grewia flavescens juss, Ethanolic extract was studied for oral acute toxicity using type of Examinations like Clinical symptoms, Mortality, Body weight, Pathological examination and carrageenan induced paw edema, method for studying anti-inflammatory activity respectively. The results of the acute toxicity studies indicate that the LD50 of Ethanolic Extract of Grewia Flavescens juss (EECF) is more than 2000mg/kg. mortality was not observed in any group. Effect of various drugs on anti- inflammatory activity was evaluated by using carrageenan induced paw edema method. Percentage of anti-inflammatory increased in EEGF groups when compared to carrageenan induced animals. The different concentration of Grewia flavescens juss showed prompt anti-inflammatory activity.

Keywords: Grewia flavescens juss, Ethanolic extract, acute toxicity, anti-inflammatory.