PULSATILE DRUG DELIVERY SYSTEM: A PROMISING DELIVERY SYSTEM FOR CONTROLLED DRUG RELEASE

Ram Chandra Jat*, Kanika Arora, Nidhi Anuragi, Rakhi Kaushal, Dr. Vinay Jain

ABSTRACT

Pulsatile drug delivery system is the most interesting, time and site specific system. This system is designed for chronopharmacotherapy which is based on the circardian rhythm. The present study is aiming at the development of chronotherapy, designed according to the chronological behavior of body. Although oral delivery has become a widely accepted route of administration of therapeutic drugs, the gastrointestinal tract presents several formidable barriers to drug delivery. PDDS can be classified into time controlled systems wherein the drug release is controlled primarily by the delivery system; stimuli induced PDDS in which release is controlled by the stimuli, like the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. Thus it is important to develop new drug delivery systems to achieve pulsed delivery of a certain amount of drugs in order to mimic the function of the living systems, while minimizing undesired side effects. Therefore Pulsatile drug delivery is one such systems that, by delivering drug at the right time, right place and in right amounts, holds good promises of benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension.

Keywords: Pulsatile drug delivery, chronotherapy, lag time, Circadian rhythm.