SYNTHESIS OF SUBSTITUTED STARCH GRAFTED METHYL NADIC ANHYDRIDE AS DRUG COPOLYMER

Firyal M. Ali and *Mohammed A. Farhan

ABSTRACT

In this research the structural modification of starch was carried out with methyl nadic anhydride (M1) as a spacer by using ceric ammonium nitrate (CAN) as an initiator, and grafted copolymer was substituted with amino drug such as amoxicillin (M1A), this design of carries for controlled delivery of therapeutic agent which could release the entrapped drug over an extended period of time ,due to its non toxic, biodegradable and slow digesting nature, the new drug copolymer was characterized by FTIR, 1H-NMR and UV Spectroscopes. Thermal analysis was studied. The physical properties were measured. The prepared drug copolymer was analyzed in different pH values at (37 0C) as in vitro study and controlled drug release was compared at zero time and after four days.

Keywords: starch, methyl nadic anhydride, amoxicillin, Copolymer, Drug Copolymer.