A NEW FLAVONE GLYCOSIDE AND THE STUDY OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF FICUS LAURIFOLIA

Hatem S. Abbass*, Ehab A. Ragab, Abd El-Salam I. Mohammed and Atef A. El-Hela

ABSTRACT

A new compound; chrysoeriol 7-O-(6``-methylglucuronoide) (1) and seven known compounds; chrysoeriol 7-O-glucuronoide (2), luteolin 7-O-β-D-glucopyranoside (cinaroside) (3), salicyl alcohol glucoside (salicin) (4), 2`-acetylsalicortin (5), 2-(β-D-glucopyranosyloxy)-benzyl (3,4-dihydroxy) cinnamoate (populoside) (6), 2-(β-D-glucopyranosyloxy)-benzyl (4-hydroxy) cinnamoate (populoside B) (7) and β-sitosterol (8) were isolated for the first time from Ficus laurifolia. The identification of these compounds was based on their NMR, UV, IR and ESIMS analyses. The alcoholic extract, ethyl acetate and n-butanol fractions showed good analgesic and anti-inflammatory activities. The n-butanol fraction appeared to be the most active one.

Keywords: Ficus laurifolia, phytoconstituents, analgesic and anti-inflammatory activities.