CORRELATION BETWEEN HEXOKINASE AND MDA IN TYPE 2 DIABETES MELLITUS

Dr. Utpal J. Dongre and Dr. V.G. Meshram*

ABSTRACT

Hexokinase catalyses the first step of glycolysis and located in the inner mitochondrial membrane. MDA is used as a marker for oxidative stress which is imbalance between free radicals and their scavenging enzymatic and non enzymatic antioxidants. For present study, we selected patients having history of maternally inherited type 2 diabetes mellitus, which are more prone to oxidative stress induced cellular damages due to mitochondrial dysfunctions. Increased oxidative stress may cause hexokinase inactivation, which may lead to severity of diabetes due to inappropriate glucose metabolism. Therefore, this study has been undertaken to evaluate activity of hexokinase enzyme in oxidative stress.

Keywords: Hexokinase, MDA, type 2 diabetes mellitus, glycolysis.