SYNTHESIS AND MICROBIAL EVALUATION OF SOME NEWER 6-(3-(1, 2-DIHYDRO-6-PHENYL-2-THIOXOPYRIMIDIN-4-YL) PHENYL AMINO) PYRIDAZIN-3(2H)-ONE VIA A NOVEL CHALCONE SERIES.

Shrikrishna D. Tupare* and Rajendra P. Pawar

ABSTRACT

Several substituted pyridazone derivative of acetophenone are condensed with aromatic aldehydes, and resulting chalcones are used for the synthesis of diaryl thiopyrimidines. Organic compounds containing pyrimidines, thiopyrimidines as a core unit are known to exhibit various biological activities and pharmaceutical activities. So, all newly synthesized compounds were screened for their antimicrobial activity. Most of the compounds showed significant antibacterial and antifungal activities.

Keywords: Pyridazone, pyrimidines, thiopyrimidines, Antifungal, Antibacterial.