ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF GREWIA FLAVESCENS JUSS WHOLE PLANT IN RATS.

*G.N. Pramodini, Dr. K. Appanna Chowdary, Parwez Alam and Seema Firdouse

ABSTRACT

Peptic ulcer disease is one of the most common gastrointestinal diseases. This affects approximately 5-10% of people during their life. As herbal medicine are potentially used in gastric ulcer prevention or management, because it has less side effect and efficient enough to be taken. Here present study has carried out to investigate antiulcer activity of ethanolic extract of Grewia flavescens juss (EEGF), Family-Tiliaceae whole plant in pylorus ligated and aspirin induced ulceration in the albino rats. Where ulcer scone, ulcer index and percentage inhibition of ulceration was determined for pylorus ligation and aspirin induced ligation models at doses of 100mg/kg, 200mg/kg and 400mg/kg for both methods taken as low doses, medium dose and high dose respectively. Antiulcer effect of EEGF was compared with standard drug ranitidine 10mg/kg (b.w., p.o). These observations helped us to conclude that ethanolic extract of Grewia flavescens juss. Posses significant antiulcer properties.

Keywords: Grewia flavescens juss, Ethanolic extract, antiulcer activity.