INVESTIGATION OF THE INFLAMMATORY AND PROTHROMBOTIC HEMATOLOGICAL INDICES IN THE PATIENTS WITH METABOLIC SYNDROME

Serdar Olt, MD.*

ABSTRACT

Background: Metabolic syndrome is the most important health problem in the world in recent years and is closely related to the development of diabetes mellitus, hypertension, hyperlipidemia, cardiovascular diseases, cerebrovascular diseases, chronic renal failure and some types of cancer. Therefore it thought to be an inflammatory and prothrombotic condition. Increased Mean Platelet Volume (MPV) has recently been claimed to initiate thrombotic processes by activating platelets in a number of studies. Also Neutrophil to Lymphocyte Ratio (NLR) has been associated with inflammatory processes in many studies. Herein our aim was to evaluate the value of MPV and NLR values in metabolic syndrome. Methods: 236 patients admitted to the department of internal medicine were included into this present study. Demographic and laboratory data of the patients were retrospectively evaluated. Metabolic syndrome was diagnosed according to NCEP ATP III criteria. Patients were divided into two groups according to presence of the metabolic syndrome; metabolic syndrome positive group and negative group. The recorded data were compared between these groups. Data were analyzed by SPSS for Windows (version 21.0; SPSS / IBM, Chicago, IL). Results: Metabolic syndrome was diagnosed in 125 patients (52,9%). There was no statistically significant difference between MPV and NLR values between the groups (p value> 0.05). Conclusion: According to the results of this present study, we can say that there was no significant correlation between metabolic syndrome and indicators of the subclinical inflammation (NLR) and platelet activation (MPV).

Keywords: Metabolic syndrome, Mean Platelet Volume, Neutrophil to Lymphocyte Ratio.