EFFECT OF TARTRAZINE ORALLY ADMINISTERED ON THE LIPID PROFILE OF ALBINO RATS

*Elekima Ibioku, Nwachuku, Edna Ogechi and Ben-Chioma Adline Erinma

ABSTRACT

In this study the effect of tatrazine on lipid profile of albino rats were evaluated. Thirty (30) rats weighing approximately 0.14kg were used in this study. The rats were divided into five (5) groups of six (6) rats per group. Lipid parameters such as Total Cholesterol (TC), triglyceride (TG), High Density Lipoprotein-cholesterol (HDL-C) and Low density Lipoprotein-cholesterol (LDL-C) were evaluated. Results obtained were analysed using graphpad prism 5.1 with statistical significance observed at P <0.05. When tartrazine treated rats were analysed, group 1 had 0.994± 0.175, 1.745±0.063, 1.203±0.065 and 0.0910±0.067 for TG, TC, HDL-C and LDL-C. Group 2 had 1.316 ±0.078, 2.791 ±0.895,1.616±0.453 and 0.577±0.583 for TG, TC, HDL-C and LDL-C respectively. Group 3 had 1.113±0.371, 1.812±0.283, 1.076±0.078 and 0.230±0.225 for TG, TC, HDL-C and LDL-C respectively. Group 4 had 1.215±0.117, 1.784±0.152, 0.979±0.065 and 0.253±0.198 for TG, TC, HDL-C and LDL-C respectively while group 5 had 1.269±0.191, 1.900±0.111, 1.092±0.029 and 0.231±0.149. The comparison of group 1 and group 2 revealed that TC and TG was significantly increased (p<0.05) while there was a non-significant decrease and increase in HDL-C and LDL-C respectively (table 4.1). The comparison of group 1 and group 3 showed a significant decrease in HDL-C levels (p<0.05) while TG, TC and LDL-C were non-significantly increased (table 4.2). Comparison of group 1 and group 4 showed a significant increase and decrease in TG and HDL-C respectively (p<0.05). However, non-significant increases were seen in TC and LDL-C levels. Finally, the comparison of group 1 and 5 indicated a significant increase in TG, TC and a significant decrease in HDL-C (p<0.05). Non-significant increase was observed in LDL-C level as well.

Keywords: Tartarzine, cholesterol, triglycerides, HDL-C, LDL-C.