SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL TRISUBSTITUTED QUINAZOLINE 1, 2, 4 TRI AZOLE DERIVATIVES BEARING CIS-SUBSTITUTED PYRROLIDINE AND SULPHONE MOIETIES.

K. Sudhakar Babu, V.Prabhakar*, L.K. Ravindranath, M.Swarna Kumari, J. Latha

ABSTRACT

Quinazoline moiety associated with different heterocycle scaffolds gives rise to a new class of hybrid heterocycles possessing improved activity. Heterocycles containing sulphur and nitrogen atoms in the core structure, shows number of pharmacologically and biologically active compounds. So, various Quinazoline derivatives were studied in the past decade and were found to possess remarkable pharmacological properties. The present Researsch Investigation provides a broad view of the biological and medicinal properties expressed by compounds having Quinazoline nucleus.

Keywords: Heterocycles, Tri azoles, Sulphones, Biological, Pharmacological Significance, Anti microbial.