SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF SUBSTITUTED THIETES - A REVIEW

Yogesh Waghmare*, Vilas Kamble and Sonali Mahaparale

ABSTRACT

This chapter describes all the aspects of chemistry of mono cyclic Thietanes and Thietes. It is based on the literature, which appeared within the period 1996–2005. Thiete is a hetero cyclic compound containing an unsaturated four-member ed ring with three carbon atoms and one sulphur atom. The next three sections deal with the synthesis of mono cyclic Thietanes and Thiete rings. One of them describes syntheses from a cyclic compounds classified by number of ring atoms contributed by each component, the second the ring synthesized by transformation the act of changing in form or shape of other ring systems. The last section is about the biological and synthetic applications of mono cyclic Thietanes and Thietes.

Keywords: Thaitane, biological activities, lead molecules, synthetic schemes.