PREPARATION AND CHARACTERIZATION TERNARY INCLUSION COMPLEXES OF HYDROCHLOROTHIAZIDE IN ?-CD AND POLYETHYLENE GLYCOL

Akshay Lohar, Pallavi Dhekale, Omkar Bhandwalkar* and Dr. Adhikrao Yadav

ABSTRACT

The aim of present research was to formulate and characterize inclusion complexes between β-cyclodextrin (β-CD) and Hydrochlorothiazide (HCT). Equimolar HCT/ β-CD solid system in the presence and absence of 0.2% (w/v) polyethylene glycol was prepared by kneading method. A phase solubility study was done to estimate solubility constant (KS) and complexation efficiency (CE). Improvement of KS and CE showed the additive effect of auxiliary substances (polyethylene glycol). The dissolution properties of binary and ternary systems were determined and compared with HCT alone. The ternary system has shown several times faster than the binary system of HCT. The optimized binary and ternary systems were characterized by phase solubility, FTIR, SEM, and DSC. These results showed that ternary inclusion complexes were formed.

Keywords: HCT, ?-CD, Kneading method, Dissolution rate, Scanning Electron Microscopy.