DIAGNOSTIC AND TREATMENT OPTIONS OF HEPATORENAL SYNDROME IN CIRRHOSIS

Aparna Thomas, Krishnakumar K, Panayappan L, Leo Mathew*

ABSTRACT

Hepatorenal syndrome (HRS) is a serious complication in patients with advanced cirrhosis and ascites, having marked circulatory dysfunction and acute liver failure. The most effective treatment option for HRS is liver transplantation. Patients with type 1 HRS generally have a fatal outcome without expedited liver transplantation. Also newer treatments such as combination of vasoconstrictor plus albumin, TIPS and MARS help in the effective management of renal function in patients with HRS. Among these, the combination therapy improves the survival in patients with type 1 HRS. CRRT and MARS in selected patients is life saving while waiting for OLT. Thus these newer therapeutic approaches have improved the management of HRS in cirrhosis patients.

Keywords: Hepatorenal syndrome, cirrhosis, AKI in liver disease, functional renal failure in liver disease, OLT, vasoconstrictors, TIPS.