TO ASSESS THE WOUND HEALING PROPERTY OF TOPIRAMATE – EXCISION MODEL IN IMMUNOSUPRESSED ALBINO RATS

Dr. Dwajani S.*, Abhijit B.R. and Dr. Sahajananda

ABSTRACT

Aim: To evaluate the wound healing activity of Topiramate [TPM] in excision model and to study its effects on Dexamethasone suppressed wound healing. Methods: For assessment of wound healing activity excision model was used. Group I received distilled water, orally, Group II, Group III and Group IV received increasing doses of TPM, p.o, Group V received Dexamethasone intramuscularly (i.m) and Group VI, Group VII, Group VIII received Dexamethasone i.m and TPM, p.o. Parameters observed were epithelization and wound contraction of excision model. Results: The TPM exhibited significant wound healing activity as compared to control in excision wound model. No statistical significant results were shown in any of the groups treated with dexamethasone. Discussion: Since TPM to certain extent enhances wound contraction it would have either enhanced contractile property of myofibroblasts or increased the number of myofibroblasts recruited into the wound area. Hence, it is concluded that TPM may be capable of promoting wound healing activity.

Keywords: Wound Healing, TPM, Dexamethasone, Excision.