ONE-POT MICROWAVE-ASSISTED DRY SYNTHESIS OF MISONIDAZOLE AND ITS O-PHENYL ANALOGUE

*Kandarpa Phukan

ABSTRACT

A short, efficient, environmental benign synthesis for 1-(2-nitro-1-imidazolyl)-3-methoxy propanol, misonidazole (MISO) and 1-(2-nitro-1-imidazolyl)-3-phenoxy propanol starting from 2-aminoimidazole and sodium nitrite using microwave irradiation supported by a natural iron rich kaolinite clay is described. This method helps to avoid conc. H2SO4 in the synthesis of these bioactive 2-nitroimidazole derivatives.

Keywords: 2-aminoimidazole, sodium nitrite, 2-nitroimidazole, 1,2-epoxy-3-phenoxy/methoxypropane, misonidazole, natural kaolinite clay, microwave-assisted reactions.