PROTECTIVE EFFECT OF EMBLICA OFFICINALIS ON HISTOPATHOLOGICAL CHANGES IN RATS INDUCED WITH POTASSIUM DICHROMATE

Dr. Kader Asen Fathima* and Kalapuram Sivaraman Priyanka

ABSTRACT

Potassium dichromate is a common inorganic chemical reagent, most commonly used as an oxidizing agent in various laboratory and industrial applications. Prolonged exposure to the chemical causes hepatotoxicity, nephrotoxicity and oxidative stress damage of reproductive organs of both male and female. A single dose of Potassium dichromate (15mg/kg, b.w.i.p) dissolved in sterile saline (0.9% Nacl) induced histological alterations in liver, kidney and testis of male wistar rats. Pretreatment with Emblica officinalis at doses of 250 mg/kg body weight, prior to intoxication of Potassium dichromate prevented tissue damage. The results obtained in the study revealed the protective effect of Emblica officinalis.

Keywords: Potassium dichromate, Emblica officinalis, Hepatotoxicity, Nephrotoxicity, Testicular damage.