STUDIES OF PHYSICOCHEMICAL PROPERTIES AND LIPOPHILICITY OF PYRIDAZINE DERIVATIVES: AN OVERVIEW

Massud A. S. Anwair* and Anisa Elhamili

ABSTRACT

These physicochemical properties and lipophilicities review studies cover all spectroscopy methods that were used for the analysis of pyridazine derivatives structures such as calculation of N-N bond lengths, angles and electron densities. These analysis indicate the planarity and N-N single bond characteristics of these derivatives and shown no protonation or quaternization affect the bond lengths with the ring. These physicochemical properties review studies also include tautomerism, surface tension, density, melting and boiling point of many pyridazine derivatives. However, and due to the relationship between the biological activities and lipophilicities properties of these compounds, so the lipophilicity and their methods of determination were also studied. Some specific pharmacological activities such as antitumor which are related to structure activity relationship of pyridazine derivatives have also reported.

Keywords: Pyridazine, tautomerism, quaternization.