FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF DOMPERIDONE

Kondapuram Parameshwar*, Mounika Diyya Bharath, Muthadi Radhika Reddy, Chindam Suresh and T. Aneesha

ABSTRACT

This work aims at investigating effect of concentration and type of polymer on formulation aspects of sustain release matrix tablets of anti-emetic containing 30 mg of a domperidone. The tablets were prepared by direct compression method because the flow property of drug was good. The Influence of concentration of polymer, type of polymer and mixture of polymers were studied with a view to optimize the formulation of domperidone. Prior to compression, different formulations were evaluated for flow and compression characteristics. All formulations were studied for in vitro drug release. The results showed that the optimum formulation (containing Carbopol 50% concentration) was able to retard the drug release up to 24 hrs. Release kinetics and mechanism of drug release from the formulation were also studied. The prepared tablets showed good mechanical properties. Tablets having Carbopol polymer showed good sustained release property and good reproducibility.

Keywords: Domperidone, sustained release, direct compression, effect of concentration of polymer.