SURFACE MODIFIED NANOPARTICLES: A MPS OPPOSING SYSTEM

Neeraj Singh*, Prabhakar Kumar Verma and Sanju Nanda

ABSTRACT

Text mining was used to extract the recent advances in the surface modification of nanoparticles to oppose uptake by Mononuclear Phagocyte System (MPS). First, we described the process of opsonization in which, non-stealth nanoparticles allowing macrophages of the MPS to easily recognize and remove them from the circulation before they attain their designated therapeutic function. Then to address these limitations, various methods have been elaborated to camouflage nanoparticles from the MPS. Of these methods particular focus has been done on the literature concerning adsorption of different polymers (like PEG, Poloxamers, Poloxamines etc.) to the surface of nanoparticles. This review highlights the advances and applications of surface modified nanoparticles along with their characterization.

Keywords: Stealth Nanoparticles, Long Circulating Nanoparticles, MPS-avoidance system.