SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL COMPOUNDS OF 3-AMINO-1-(2, 5-DIFLUOROBENZOYL)-4-(2-(4-NITROPHENYL) HYDRAZONO)-1H-PYRAZOL-5(4H)-ONE MOIETIES

M. Swarna Kumari*, K. Sudhakar Babu, L.K. Ravindhranath, J. Latha,
V.Prabhakar

ABSTRACT

New novel derivatives of 3-amino-1-(2,5-difluorobenzoyl)-4-(2-(4-nitrophenyl) hydrazono)-1H-pyrazol -5(4H)-one were prepared by condensation of of ethyl 2-isocyano-2-(2-(4-nitrophenyl) hydrazono)acetate (3). The synthon (3) was obtained by the condensation of 1,4- di fluoro benzoyl hydrazide(2) with Ethyl 2-(2-(4-(tri fluoromethyl) phenyl) hydrazono)-2-iso cyano acetate(1). The synthon(1) was obtained by the condensation of 1-chloro-2-(4-(trifluoro methyl) phenyl)diazene(A) with ethyl-2-iso cyano acetate (B). The newly synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectra & Elemental analysis. The newly synthesized compounds were screened for their Biological activity.

Keywords: Pyrazolone-5-one, Antibacterial and Antifungal activity.