A REVIEW: FLOATING PULSATILE DRUG DELIVERY SYSTEM

Sardar Shelake*, Akshay Shinde, Nigar Mujawar, Pratiksha Jadhav, Sachinkumar Patil and Shitalkumar Patil

ABSTRACT

In the recent years, scientific and technological advancements have been made in the research and development of novel drug delivery systems by overcoming physiological troubles for e.g.as short gastric residence times and unpredictable gastric emptying times. Several approaches are currently utilized in the prolongation of the gastric residence times, including floating drug delivery systems, swelling and expanding systems, polymeric bio adhesive systems, modified shape systems, high-density systems and other delayed gastric emptying devices. By using floating drug delivery help in avoiding dose dumping gives desirable release as controlled & delayed. A blend of floating and pulsatile principles of drug delivery system seems to present the advantage that a drug can be released in the upper GI tract after a definite time period of no drug release. Floating pulsatile drug delivery system (FPDDS) concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. Diseases wherein FPDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, and attention deficit syndrome in children. To overcome limitations floating and lag controlling were prepared by floating pulsatile delivery systems, for which time controlling system like swelling and rupturablemembranes, soluble or erodible coating, capsule shaped system and multiparticulate system are primarily involved in the control of release.

Keywords: Gastric residence time, Floating drug delivery system, Chronotherapeutic, lag time, avoid dose dumping.