ANALYSIS OF NEUROTOXIN METALS IN THE CSF SAMPLE OF MOTOR NEURON DISEASED PATIENTS.

Dr. Ranvir Singh Yadav, Garima Gupta*, Dr. Arun Singh, Dr. VN Mishra, Dr. Deepika Joshi

ABSTRACT

Motor neuron disease (MND) is a disorder of the nervous system characterized by atrophy of skeletal muscle and sclerosis of motor pathways in brain and spinal cord. Toxic metal have been implicated in the pathogenesis of MND however the exact mechanism is not known here we have analyze 3 neurotoxin metals in two type of MND cases total 35 patients of MND were taken out of which 20 were of ALS &15 were of JASSMA. Metal analyses were performed with high- resolution inductively coupled plasma mass spectrometry. Statistically significant difference in the level of heavy metal can be observed in both type of MND this result support the hypothesis that heavy metal may play an important role in the pathogenesis of MND.

Keywords: juvenile asymmetric segmental spinal muscular atrophy.ICP, QEMG,CSF