EVALUATION OF ANTI-MICROBIAL (IN-VITRO) ACTIVITY OF ARICLEANSE CAPSULE

*Dr. Sanjay Nipanikar, Dr. Dheeraj Nagore, Dr. Snehal Agnihotri, Dr. Suneeta Panicker, Nivedita Shelke

ABSTRACT

As a therapeutic agent for acne, antibiotics are typically employed to kill bacteria and as a result inflammation is reduced. However, antibiotic resistance has been increasing steadily within dermatologic setting. The development of antibiotic resistance is multifactorial. To overcome the problem of resistance, medicinal plants have been extensively studied. The potential use of traditional herbal medicines as a basis for new skin care cosmetics has been emphasized recently. It is of great importance to determine whether preparations used cosmetically in folk medicine have activities that could be useful in modern formulations. Propionibacterium acnes and Staphylococcus epidermidis are commonly detected in acne lesions, and Staphylococcus aureus is a common cause of skin infections. Propionibacterium acnes and Staphylococcus epidermidis are pus-forming bacteria that trigger inflammation in acne. In efforts to find new formulation of different herbal extracts for effective management of Acne vulgaris, Ari Healthcare Pvt. Ltd. has developed Aricleanse capsule containing Guduchi extract (Tinospora cordifolia), Manjishtha extract (Rubia cordifolia), Sariva extract (Hemidesmus indicus), Nimba extract (Azadirachta indica), Khadira extract (Acacia catechu), Kakmachi extract (Solanum nigrum), and Yashtimadhuka extract (Glycyrrhiza glabra) which are known for their antimicrobial activities. Aricleanse capsule when tested against Staphylococcus auerus Staphylococcus epidermidis and Propionibacterium acnes was found to be active as compared to the standards Clindamycin and Doxycycline. Thus, we can conclude that Aricleanse capsule possesses antimicrobial activity and may be used to treat acne vulgaris and other skin diseases caused due to Staphylococcus auerus and Staphylococcus epidermidis.

Keywords: Aricleanse capsule, Acne, Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus auerus.