NOVEL OCULAR SUSTAINED RELEASE FLURBIPROFEN INSITU GELS DEVELOPMENT AND IN-VITRO EVALUATION

Abdul Mannan, Zeba Begum* and Khizra Nishat

ABSTRACT

Insitu gelation is a process of gel formation at the site of application, like ocular region. Insitu gel phenomenon based upon liquid solution of drug formulation and converted into mucoadhesive semi-solid. So that it can overcome the drawbacks of conventional eye drops like poor therapeutic response, because of high tear fluid flow dynamics. And also the high frequency of eye drop instillation is associated with patient non-compliance. In the present project, insitu gels were prepared by utilising various concentrations of pH responsive gelling agents like carbopol 934, sodium alginate, chitosan, and viscosity modifier agent HPMC K4M is used. From the nine formulation trails F1-F9, formulation F6 containing 0.8% of HPMC K4M and 0.5% of Carbopol 934 was found to be optimised. The developed optimised formulation was tested for various in-vitro quality control tests and was found to sustaining the drug release upto 8 hours, was stable, non-irritant and found to be sterile in the performed tests. The developed system thus could be a viable alternative to the conventional eye drops.

Keywords: Insitu Gelling, Flurbiprofen, Sustained Delivery.