A STUDY OF INFLAMMATORY MARKERS (CRP, ADA & ESR) IN HYPOTHYROIDISM

Shyam Sundar Yadav*, G. P. Singh and Sushil Yadav

ABSTRACT

Background: Hypothyroidism slows down the metabolic activities producing various causes weight gain, poor appetite, shortness of breath constipation etc. These are associated with the immune deregulation which ultimately produces the inflammation. Inflammatory markers can be helpful assessment in diagnosis of hypothyroidism is not very well studied in the past. So, the goal of the study is to investigate role of these inflammatory (CRP, ADA &ESR) in hypothyroidism. Material and Methods: The study consists of 30 patients diagnosed with hypothyroidism and 30 healthy controls. The serum Total TSH, T3 &T4 were estimated by enzyme immunoassay competition method with ELFA technique by using automated VIDAS for the conformation of hypothyroidism. The concentration of CRP and ADA activity were determined on semi auto analyzer by quantitative turbidimetric methods. Similarly, ESR level were estimated by westergren tube method. Results: In the study, the mean CRP value (10.66±7.81) mg/dl, ADA (24.47±6.47) U/L & ESR (16.57±5.68) mm/hr were found significantly higher in hypothyroid patients in comparison to healthy controls. Similarly, there was no correlation obtained between TSH, T3 &T4 and CRP, ADA & ESR. Conclusion: The study has shown that there is significant increase in mean CRP, ADA &ESR level in hypothyroid patients in comparison to healthy controls.

Keywords: ADA, CRP, ESR, Hypothyroidism.