ASSESSMENT OF PREVALENCE OF KANAMYCIN INDUCED OTOTOXICITY IN MDRTB PATIENTS IN TERTIARY CARE HOSPITAL, (INDIA)

Ashishkumar C Zala*, Nitesh Gamit, Ruchita M Manvar, N D Kantharia

ABSTRACT

Background: Standard treatment of MDR-TB (multidrug resistant tuberculosis) consists Category IV regimen of RNTCP. Although this regimen is effective in treating MDR TB, it is associated with many adverse drug reactions (ADRs) Aim and objective: To assess incidence of ototoxicity in MDR-TB patients in tertiary care hospital and causality assessment of reported ADRs using suitable scales. Methods: In this prospective, observational study, patients selected from TB & chest OPD was evaluated for deafness before and after treatment. The nature of the ADRs, likelihood of association with the study medications and severity were evaluated. Result: kanamycin used in MDR-TB patients may result in mild to moderate bilateral sensorineuronal type hearing loss. Careful audiologic monitoring may help in limiting this damage which once developed is permanent.

Keywords: MDRTB, Kanamycin, Hearing loss, ADRs.