FORMULATION AND OPTIMISATION OF CONTROLLED RELEASE TABLETS OF AMBROXIL HYROCHLORIDE TABLETS

A. Rajesh* and K. Swapna

ABSTRACT

In the present work, an attempt has been made to prepare controlled release matrix tablets of ambroxol hydrochloride, a mucolytic expectorant by wet granulation method using xanthan gum as natural hydrophilic polymer in three different ratios (Drug : Polymer 1:1,1:1.5, 1:2) .The prepared granules of three different formulations were evaluated for angle of repose, loose bulk density (LBD), tapped bulk density (TBD) and compressibility index(CI), hausners ratio and This was further supported by lower compressibility index values. Generally CI values up to 15% results in good to excellent flow properties. the percentage porosity values of the granules ranged from 26.92% - 34.52%, indicating that the packing of the granules may range from close to loose packing and also conforming that the particles are not of greatly different sizes. The prepared tablets were tested for physical parameters like weight variation, hardness, friability, content of active ingredient and In-vitro drug release studies. The percent deviation is with in the prescribed official limits.

Keywords: In the present work, with in the prescribed official limits.