RISK-BENEFIT ASSESSMENT BETWEEN INHIBITION OF ANGIOTENSIN CONVERTING ENZYME (ACE) AND MELANOGENESIS OF MEDICINAL HERB, VIOLA MANDSHURICA

Ji Hun Jo, Seok Hyeon Moon and Man Kyu Huh*

ABSTRACT

Food substances are recognized to have the potential to exert both health benefits and health risks. The Scientific Committee of the European Food Safety Authority (EFSA) developed guidance for performing risk-benefit assessments of food. We applied chemical and biological hazard assessments of Korean Ministry of Food and Drug Safety recommends to risk-benefit aspects. A mathematical model by Tallarida’s the severity of diseases and adverse drug reactions is derived from these weights and categories to calculate the observed benefit-less-risk score for an individual. For inhibition of angiotensin converting enzyme (ACE), the profit is 13.927. For melanogenesis (biochemical pathway of melanin), the profit is -11.66. Potential risks of medicinal herb, V. mandshurica intake must be considered in the context of potential benefits.

Keywords: EFSA, mathematical model by Tallarida, risk-benefit, Viola mandshurica.