DEVELOPMENT OF SPECTROPHOTOMETRIC METHOD FOR DEGRADATION STUDY OF LORNOXICAM

Gaikwad Pranali*, Shelake Sardar Nigar Mujawar and Shitalkumar Patil

ABSTRACT

The main objective of this paper is to develop simple, precise, accurate stress degradation assay method for Lornoxicam. Lornoxicam, a non-steroidal anti-inflammatory drug (NSAID).For present work ACN: Water (70:30) was used as mobile phase. The drug showed λmax at 382 nm. The method obeys Beers-Lamberts law in the concentration range of 5-30 μg/ml for UV analysis. From the degradation studies Lornoxicam showed sufficient degradation in acidic and alkaline degradation. Lornoxicam was found to be less susceptible to oxidative degradation. No degradation was observed in photolytic and thermal degradation. There was no significant difference observed in degradation pattern of bulk drug and pharmaceutical formulation. ICH guidelines were followed throughout the degradation studies and the proposed method found accurate stress degradation assay method. The proposed method is precise, accurate and stability indicating. Thus the proposed method can have its application in the determination, of Lornoxicam in bulk drug, as well as in presence of its degradation products.

Keywords: Lornoxicam, Stress degradation, UV analysis, Beers-Lamberts law NSAID.