SYNTHESIS OF NOVEL OXADIAZOLE DERIVATIVES WITH QUINAZOLINONE MOIETY AS POTENT ANALGESIC AGENTS

Dr. Indu Singh*

ABSTRACT

A novel series of N-(6-bromo-2-methyl-4-oxaquinazolin-3(4H)-yl)-2-(5-(substituted phenyl)-1,3, 4-oxadiazol-2-ylthioacetamide (10-12) have been synthesized from 2-(5-(substituted phenyl)-1,3,4-oxadiazol-2-ylthio) acetyl chloride (7-9) with the aim to get better analgesic agents with minimum side effects. Structure the newly synthesized compounds were supported by means of elemental analysis and IR and 1HNMR spectral analysis. Title compounds were evaluated for their analgesic activity and compared with standard drug phenylbutazone. In this series compound 12 showed better analgesic activities than standard drug.

Keywords: Oxadiazole, quinazolinone, analgesic activity, phenylbutazone.