ACQUIRED BLEEDING DISORDER DUE TO SECONDARY ANTIPHOSPHOLIPID SYNDROME IN A YOUNG FEMALE- CASE REPORT

Dr. Lalit P. Meena*, Siddharth Samrat, Priyanka Singh, Jaya Chakravarty Madhukar Rai and Shyam Sundar

ABSTRACT

Antiphospholipid Syndrome (APLA)is an autoimmune disease which is more commonly presents with arterial and venous thromboembolism rather than bleeding.We present a case of Secondary Anti phospholipid syndrome without thrombocytopenia in a 16 year old unmarried female presented with isolated per vaginal bleeding with deranged PT/INR, aPTT. Serum ANA and Anti dsDNA were positive withthe presence of ACLA IgG/IgM antibodies. Mixing study and factor VIII activity assay showed the presence of antibodies against factor VIII.

Keywords: Antiphospholipid syndrome, Lupus anticoagulant, Acquired Factor inhibitor, Acquired bleeding disorder.