DESIGN AND INVITRO EVALUATION AND COMPARISON OF HP?CD AND ? CD COMPLEXED ALBENDAZOLE JELLY

Anjana M. N.*, Mathew George and Lincy Joseph

ABSTRACT

A high dosage of albendazole (ABZ) is required for treating systemic helminthe infections because of its low solubility. Aiming at increasing ABZ solubility, complexation with beta-cyclodextrin (β-CD)and hydroxyl propyl beta cyclodextrin(HP βCD ).In this research work ABZ is complexed with cyclodextrins and oral jellies are formulated and comparison was done .One of the benefit of this formulation is these prepared jellies are increased bioavailability by-passing first pass metabolism. Difficulty in swallowing (dysphagia) is common among all groups, especially in elderly and pediatrics. Jelling agent is dispersed in water and jellies were prepared and jellies were evaluated for physical characteristics such as pH,in vitro % drug release, content uniformity, spreadability, viscosity, IR spectral analysis, syneresis .In vitro dissolution was carried out using the paddle method.

Keywords: Jelly, Dysphagia, Albendazole, In vitro dissolution studies, HP ?CD, ?CD.