FORMULATION AND EVALUATION OF TDDS OF FLUVASTATIN SODIUM

Putta Swathi*, Nikunja B. Pati, G. Supriya and G. Vasanth Nayak

ABSTRACT

The aim of the present study was to develop transdermal patch of Fluvastatin sodium with different permeation enhancers and release retarding polymers to achieve extended-release of Fluvastatin sodium . Fluvastatin sodium transdermal patch prepared by solvent casting method. Different formulations were prepared by changing the different release retarding polymers and different permeation enhancers to check the impact of polymer and permeation enhancers on the performance of prepared patches. All the patches were uniform and translucent. These were having good strength and visually smooth surfaced. The patches were evaluated based on their physical characteristics like, film thickness, folding endurance, percentage moisture content ,moisture uptake and their evaluation like, drug content uniformity and in vitro drug permeation study. The patches show thickness values in between 0.1 cm to 0.2cm, Folding endurance was found to be in the range of 106 for formulation F6. Similarly, the patches are also subjected to drug content uniformity study which suggest uniform dispersion throughout the transdermal patches. In vitro permeation studies using egg membrane shows highest drug release for HPMC100 M patch containing solid dispersion of drug with transcutol i.e., 87.27% in 8 hrs. Among permeation enhancers transcutol has improved permeation to 87.27% in 8 hrs in HPMC100 M. The mechanism of release of drug was diffusion rate limited.

Keywords: Fluvastatin sodium, HPMC 4 M, HPMC15 M, HPMC100 M, DMSO, transcutol.