STANDARDISATION OF AYA CHENDURAM, A NANOSIZED HERBO-MINERAL SIDDHA FORMULATION USING MODERN TECHNIQUES

V. Gayathri Devi*, Sreekanth Narayanaru, M. Natarajan, Anitha John and A. Kanagarajan

ABSTRACT

Standardization of Siddha preparations is an important task in establishing the safety and efficacy of the drug. The World Health Organization (WHO) guidelines on evaluating the physico-chemical properties and other parameters for the identification of AYUSH formulations which will offer a great value in global market. Characterization of Siddha formulation renders wide range of information in predicting the nature and structure of phytoconstituents which renders the actual therapeutic efficacy of the formulation. The main aim of the present study is to standardize Aya Chenduram, a nano sized formulation, and also to characterize the same by using sophisticated techniques like Fourier transform infrared spectroscopy (FTIR), Raman Spectroscopy, X – ray diffraction (XRD) and Scanning Electron Microscope (SEM) with EDAX. The X-ray diffraction studies identified that the major crystalline material present in the formulation was alpha-iron oxide. FTIR and Raman spectral data are also supported the presence of alpha iron oxide in Aya chenduram. Further, the results obtained from the SEM analysis shows that most of the particles present in Aya chenduram are in nano and near nano size ranging from 79 nm to 83 nm. In conclusion, data retrieved from the current characterization study of Aya chenduram confirms the size, shape and nature of nano-components and hence this could be used as standards for evaluating the quality of Aya chenduram in future.

Keywords: Phytoconstituents, physico-chemical.