CLINICAL AND IMMUNOLOGICAL FEATURES OF PATIENTS WITH CHD ASSOCIATED WITH TNF-A

M. Kasimova, A. Ismailova, T. Aripova, A. Kasimov and T. Hegay*

ABSTRACT

The study included 101 patients with coronary heart disease aged from 34 to 76 years (56.9 ± 0.9), of them 64.4% were men and 35.6% - women. We have shown the role of TNF-α gene (-308G> A) in the development of CHD-allele A, the A/G and A/A genotypes are characterized as risky variants in the development of unstable (progressive) stenocardia in the Uzbek population. In the group of unstable stenocardia with genotype profile A/G+A/A of TNF-α gene (-308G> A), the levels of TNF-α, IL-6, IL-18, CRP and fibrinogen were reliably higher in comparison with SS and control groups. Despite the fact that we have shown the role of TNF-α (-308G> A) in the development of CHD in the Uzbek population, further study of this SNP on much more material is necessary, in connection with the already known risk factors to establish its potential causal relationship.

Keywords: CHD, tumor necrosis factor, TNFa, interleukins, Uzbek population.