A REVIEW ON BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM

Shaikh Siraj*, Shaikh Zaker, G. J. Khan and Patel M Siddik

ABSTRACT

Purpose of this review is to compile the recent literature with special focus on various aspects of Buccal drug delivery system that gaining significance place among novel drug deliveries. Buccal drug delivery system is a novel drug delivery system. bioadhesion refers to any bond formed between two biological surfaces or a bond between a biological and a synthetic surface. Buccal mucosa is the preferred site for both systemic and local drug action. The mucosa has a rich blood supply and it relatively permeable. In Buccal drug delivery systems mucoadhesion is the most important element so various mucoadhesive polymers have been utilized in different dosages form. Various bioadhesive dosages form such as Chewing gum, tablets, Patches, Hydrogel, Thiolated tablets. In this review article the Anatomy of mucosa, advantages, disadvantages, polymers, and evaluations of the Buccal drug delivery has been discussed.

Keywords: Anatomy of Oral Mucosa, Buccal, Mucoadhesive Polymer, Permeation, Dissolution.