GENES AND ORAL CANCER: A REVIEW

Dr. Swati Dahiya, Dr. Taranpreet Kaur* and Dr. Ankit Srivastava

ABSTRACT

Carcinogenesis is a complex, multistep process in which genetic events within cell transduction pathways governing normal cellular physiology are quantitatively or qualitatively altered. It is a multistage process involving gene, or epigenetic damage in susceptible cells that gain a selective growth advantage and undergo clonal expansion as a result of activation of proto oncogene or inactivation of tumor suppressor gene or both. Multiple genetic events culminate in carcinogenesis, however, not all genetic events occur in all squamous oral carcinomas and similar genetic alterations may occur at different times in the process of carcinogenesis.

Keywords: Carcinogenesis; Genes; Oral cancer.