DEVELOPMENT AND EVALUATION OF SILVER SULPHADIAZINE LOADED SODIUM ALGINATE GELATIN FILM FOR WOUND DRESSING APPLICATIONS

Mathew George, Lincy Joseph and Liby Tresa Francis*

ABSTRACT

Aim of this study was to develop novel bio medicated film for wound dressing applications. Film of gelatin and sodium alginate loaded with silver sulphadiazine were successfully prepared by solvent casting method. The formulations were subjected to various physico chemical evaluations such as weight variation, surface pH, folding endurance, moisture evaluation studies, biodegradability and in vitro drug release studies. All the prepared films were found to be transparent, flexible with smooth surface. The results of physicochemical characteristics of Medicated films were satisfactory with respect to weight variation, surface pH, folding endurance, and moisture loss and moisture uptake studies. The drug entrapment was found to be in acceptable range for all the formulations, indicating uniform distribution of the drug. Films prepared using sodium alginate and gelatin showed satisfactory biodegradability. Thus, Gelatin-SA wound dressing system containing silver sulphadiazine could be a good polymeric membrane candidate in wound care.

Keywords: Medicated film, biodegradability, wound healing.