EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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 ISSN 2394-3211

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Abstract

SYNTHESIS AND ANTICANCER EVALUATION OF SOME CHROMENONE DERIVED CHALCONES

Richa Kaur Bhatia*, Lakhwinder Singh, Ruchika Garg, Satyavathi Kancherla, Upendra K. Jain, Nitasha Suri, Anpurna Kaul and Ajit Kumar Saxena

ABSTRACT

A new series of 6/7-substituted-chromenone chalcone derivatives (15a-d) was designed and synthesized utilizing acid catalyzed condensation methodology. The synthesized compounds were characterized by 1H-NMR, 13C-NMR, UV, ATR and mass spectroscopy, and evaluated for their cytotoxic activity against colon (HCT-116 and COLO-205), leukemia (HTP-1) and lung (NCIH-322) cancer cell lines. Compound 15d (7-Chloro-3-(3-oxo-3-(4-phenoxy-phenyl)prop-1-enyl)-4H-chromen-4-one) emerged as the most promising cytotoxic agent among all the synthesized derivatives (15a-d) by exhibiting significant IC50 against colon cancer cell line (HCT-116), can be subjected to advanced investigations.

Keywords: Chromenone, Chalcone, Anticancer, Colon Cancer.


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SJIF Impact Factor: 7.065

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