SYNTHESIS AND SCREENING OF NOVEL SUBSTITUTED INDANE 2, 3- DIONE FOR ANTICONVULSANT ACTIVITY

Mathew George, Lincy Joseph and Mincy Mathew*

ABSTRACT

Indane 2, 3- dione (isatin) derivatives have shown wide range of activities like antibacterial, antifungal, anticonvulsant etc. Particularly isatin nucleus has a lactam structure which is an important part of antiepileptic drugs (AEDs).For the synthesis of various derivatives of indane 2,3 –diones , first it was treated with ethyl chloroacetate and the resultant product was then treated with hydrazine hydrate and the hydrazides thus obtained was allowed to react with different aldehydes for the corresponding hydrazones. Hydrazones were then treated with chloramine T for the required product.

Keywords: Indane 2, 3-dione, Hydrazones, 1, 3, 4-oxadiazole, Anticonvulsant activity.