STUDY OF ANTIBACTERIAL ACTIVITY OF 7-SUBSTITUTED 1-CYCLOPROPYL-6 -FLUORO-1, 4-DIHYDRO-8-METHOXY-4-OXOQUINOLINE-3-CARBOXAMIDE DERIVATIVES

Zaki Ahmed B. Munshi, Bhikan J. Khairnar, Dhananjay V. Mane. Muftedar Ahmed I. Patel and Bhata R. Chaudhari*

ABSTRACT

Here in we report synthesis and antibacterial screening of fourteen novels 7-substituted 1-cyclopropyl-6 -fluoro-1, 4-dihydro-8 methoxy-4-oxoquinoline-3-carboxamide derivatives by substituting fluoro group at C-7 position with heterocyclic amine and substituted heterocyclic amine. All these derivatives were screened for antibacterial against P. aeruginosa and Bacillus subtilis pathogens and found encouraging result.

Keywords: Antibacterial activity, Quinoline-3-carboxamide, Gatifloxacin, Ciprofloxacin.