SYNTHESIS AND CHARACTERIZATION OF CELLULOSE GRAFTED MALEIC ANHYDRIDE AND SUBSTITUTED IT WITH AMOXICILLIN

*Mohammed A. Farhan, Hiba B. Dheyab and Assmaa A. Hasan

ABSTRACT

In this research the structural modification of cellulose was carried out with maleic anhydride (H) as a spacer by using ceric ammonium nitrate (CAN) as an initiator, and grafted copolymer was substituted with amino drug such as amoxicillin (HA), this design of carries for controlled delivery of therapeutic agent which could release the entrapped drug over an extended period of time, due to its biodegradable, non toxic and slow digesting nature, the new drug copolymer was characterized by FTIR and UV Spectroscopes. Differential scanning calorimetry (DSC) and thermo gravimetric analysis (TGA). The physical properties were measured. The prepared drug copolymer was analyzed in different pH values at (370C) as in vitro study and controlled drug release was compared at zero time and after four days.

Keywords: Cellulose, maleic anhydride, amoxicillin, Copolymer, Drug Copolymer.