EVALUATION OF ANTICONVULSANT AND ANXIOLYTIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF SYZYGIUM AQUEUM (BRUM.F)

Geethu Krishna O.*, Vishnupriya K. V., Thamodaran G., Suresh V. and Dr. Senthil Kumar N.

ABSTRACT

Syzygium aqueum (S.aqueum), a species in the Myrtaceae family, commonly called the Water apple is native to Malaysia and Indonasia. It is well documented as a medicinal plant and various parts of the tree have been used in traditional medicine, for instance as antibiotic. The plant also possess some anticancer, antioxidant and anti-hyperglycaemic activities. The objective of the present study was to evaluate the anxiolytic and anticonvulsant activity of the methanolic leaves extract of Syzygium aqueum. After acute toxicity test, oral treatment with Methanolic leaves extract of S.aqueum at doses of 125, 250, and 500 mg/kg behavioral models of elevated-plus-maze, open field, pentylenetetrazole, and maximal electroshock induced seizure models were utilized. In open field test, Methanolic extract of S.aqueum (125, 250, and 500 mg/kg) increased the number of rearings and number of square crossed. Likewise, the number of entries and the time spent in open arm were increased in elevated-plus-maze test. Methanolic leaves extract of S.aqueum (125–500 mg/kg) protected the mice against the pentylenetetrazole induced convulsions; it causes significant dose dependent increase in latency of convulsion. Treatment with Methnolic leaves extract of S.aqueum reduced the duration of the tonic hind limb extension induced by electroshock.

Keywords: S.aqueum, Anticonvulsant, Anxiolytic.